The WyoMed Campaign Organization was established in Wyoming in 2008 dedicated to helping the lives of individuals living with and associated with metabolic diseases such as PKU by advocating, being involved in research, support, education and teaming up with the National PKU Alliance to find a cure.

 

Phenylketonuria (PKU) is a rare, inherited metabolic disorder that is characterized by the inability of the body to utilize the essential amino acid, phenylalanine (Phe). Amino acids, usually obtained from the food we eat, are the building blocks for body proteins. PKU is caused by a deficiency of the liver produced enzyme phenylalanine hydroxylase (PAH).

This enzyme normally converts Phe to another amino acid, tyrosine. Without this enzyme, Phe accumulates in the blood and body tissues. Excess Phe is toxic to the central nervous system and causes the severe problems normally associated with PKU. When left untreated, PKU patients who consume too much Phe are at risk of severe neurological complications, including IQ loss, memory loss, concentration problems, mood disorders, and in some cases, severe mental retardation.

Damage done is irreversible so early detection is crucial. When treatment is begun early (within the first few weeks of life) and rigorously adhered to, affected children can expect normal development and a normal life span. PKU can be treated by a diet low in phenylalanine and high in tyrosine. While there is no cure, in recent years a few drug products have become available that can be used in limited cases to mitigate the effects of the disorder. Other therapies currently under investigation include an injectable form of PAH and gene therapy. (Retrieved from http://www.npkua.org on November 14, 2011.)

 

The WyoMed Campaign Organization is heading to the future with a strong and proactive motive. We now focus on PKU, however, as an organization we plan to focus on the other metabolic diseases other than PKU as well.